Searchable abstracts of presentations at key conferences in endocrinology

ea0077lb3 | Late Breaking | SFEBES2021

The importance of high-volume specialist centres. An audit of bilateral adrenal vein catheterization success rates

Alsafi Zaid , Wernig Florian , Alsafi Ali

Background: Adrenal vein sampling (AVS) is the gold-standard for localizing the site of autonomous aldosterone production in patients with primary aldosteronism (PA). The procedure is technically challenging with a reported success rate of 50-95%.Aim: To audit the success rate of AVS at a regional referral unit.Standards: No set standard exists. 80% success rate was taken as the minimum acceptable standard for a tertiary referral c...

ea0068p36 | Abstracts | UKINETS2019

Two case reports of preserved endocrine and exocrine function in VHL patients with extensive pancreatic cysts

El Sayed Ahmed , Boharoon Hessa , Alsafi Ali , Preitner Nadia , Kosicka-Slawinska Monika , Brady Angela , Hill Peter , Tan Tricia

Von Hippel-Lindau (VHL) disease is an inherited tumour syndrome, caused by a mutation in the VHL tumour suppressor gene encoding the VHL protein. Patients are prone to cysts and neuroendocrine tumours in the pancreas and other benign and malignant neoplasms. Pancreatic cysts occur in approximately 70% of VHL patients. We describe two cases of VHL disease with extensive multi-cystic changes affecting the whole pancreas, both patients had deletions of exon 2–3 of the VHL ge...

ea0031p187 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Acute effects of co-infusion of peptide YY (3–36) and glucagon-like peptide-1 on insulin secretion and insulin sensitivity

Tan Tricia , Salem Victoria , Troke Rachel , De Silva Akila , Alsafi Ali , Misra Shivani , Baynes Kevin , Ghatei Mohammed , Minnion James , Field Ben , Godsland Ian , Bloom Stephen R

The amelioration of type 2 diabetes and sustained weight loss after bariatric surgery are thought to be due to elevated circulating levels of the gut hormones peptide YY3–36 (PYY3–36) and glucagon-like peptide-1 (GLP-1). GLP-1 augments the insulin response to an oral glucose load. PYY3–36 has appetite-inhibitory effects and contributes to longer-term weight loss. Rodent studies provide conflicting data regarding the effects of PY...

ea0028p140 | Neoplasia, cancer and late effects | SFEBES2012

Expression of Somatostatin Receptors in Phaeochromocytoma and Paragangliomas

Parvizi Nassim , Alsafi Ali , Vergine Marco , Ramachandran Radha , Martin Niamh , Palazzo Fausto , Pinato David , Sharma Rohini , Meeran Karim , Dina Roberto , Tan Tricia

Background and Aims: Phaeochromocytoma and paragangliomas are neuroendocrine tumours arising from chromaffin cells. These tumours express somatostatin receptors (SSTRs), which has five different main subtypes (SSTR1, SSTR2, SSTR3, SSTR4 and SSTR5). The differential expression of the different receptor subtypes in these tumours has previously been reported with a small series of tumour samples. Our study examined the expression of SSTR subtypes in a larger series of benign and ...